Liverpool moved to 76 points from 32 games with title rivals Manchester City on 74 points from one game fewer, with Pep Guardiola's side hosting Brighton and Hove Albion at the Etihad on Wednesday.
Liverpool beat Arsenal at Anfield in a penalty shootout on Wednesday after their last-16 tie ended 5-5 in regulation.
Liverpool forward Sadio Mane scored his 100th goal for the club to help secure a 3-0 victory over lively Crystal Palace in the Premier League at Anfield on Saturday.
Darwin Nunez came off the bench to score twice as Liverpool snatched a sensational 2-1 Premier League win at Newcastle United on Sunday.
Man United get injury boost ahead of Liverpool FA Cup clash
Champions Liverpool were ripped apart 7-2 at Aston Villa and Manchester United were humiliated 6-1 at home by Tottenham Hotspur on Sunday in one of the most astonishing days of Premier League results.
Images from Saturday's action in the Premier League.
A summary of Saturday's action in the Premier League.
A summary of Saturday's action in the Premier League.
Reigning champions City are also involved in a separate independent hearing into the club's alleged breaches of Premier League financial regulations which began in September, with a verdict expected some time before the end of the current season.
A summary of Saturday's action in the English Premier League.
Champions Manchester City could only muster a 2-2 Premier League draw with Brighton & Hove Albion on Saturday.
Images from the English Premier League matches played on Sunday.
A summary of Tuesday night's Champions League matches.
Premier League leaders Liverpool stumbled again at home and needed two Steven Gerrard goals to salvage a draw with Hull City. Luckily for the leaders two of their title rivals also dropped points.
While Sunday's clash was the last time Klopp and Guardiola will face off for Premier League points, as far as this year's title race is concerned it merely made things even more interesting with Arsenal ahead of Liverpool on goal difference and City one point back. All three have 10 games left.
The battle for Champions League qualification continues with fourth-placed Aston Villa away to Luton Town on Saturday and Tottenham Hotspur, who are five points behind with a game in hand, hosting Crystal Palace.
IMAGES from Premier League matches played on Sunday.
Images from Saturday's action in the Premier League.
Manchester City defender John Stones headed a controversial stoppage-time winner in a 2-1 victory at Wolverhampton Wanderers on Sunday that took them top of the Premier League and set a club record of 31 league games unbeaten.
Liverpool scored twice in the opening 18 minutes to beat Chelsea 2-0 at Anfield.
IMAGES from the English Premier League matches played on Sunday.
Premier League champions Liverpool maintained their 100 per cent start to the season with a 3-1 win against Arsenal at Anfield on Monday leaving them level on nine points with pacesetters Everton and Leicester City.
Manchester City needed a second-half penalty from striker Erling Haaland to break the resistance of a dogged Crystal Palace.
Liverpool have extended captain Jordan Henderson's contract, the Premier League side said on Tuesday, putting an end to speculation over his future at the Merseyside club.
Liverpool have the joint biggest lead in top-flight history at this stage of the campaign and no team has ever failed to win the title with an advantage of this size. Already there is talk of Liverpool going through the league entire season unbeaten -- matching the 'The Invincibles' of Arsenal in 2003/04 and Preston North End in 1888/89.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
IMAGES from the UEFA Champions League matches played on Wednesday.
Images from the Premier League matches played on Sunday.
News of all that's transpired on and off the football field
A round-up of Saturday's action in the Premier League.
Images from the English Premier League matches played on Sunday.
Liverpool will resume their quest for a first top-flight title in 30 years against Everton on June 21 but the venue for the behind-closed-doors fixture was not confirmed when the league released its revised fixtures for the season's restart.
Troubled Liverpool conceded a last-gasp goal in a 1-1 draw at Olympique Lyon Wednesday, leaving them in danger of an early Champions League exit, while Inter Milan were on the right end of some late drama. Arsenal, inspired by two goals from Cesc Fabregas, thrashed AZ Alkmaar 4-1 and virtually ensured their place after becoming the only Premiership side to manage a win this week.
The Reds' manager believes his team has the ability to finish in the top four and qualify for Champions League next season.
A round-up of Tuesday's action in the UEFA Champions League.
IMAGES from the English Premier League matches played on Saturday.
Liverpool manager Brendan Rodgers has admitted that his team will struggle to make a top-four finish at the end of the season, thus virtually ending their hopes of Champions League qualification following a 4-1 defeat against Arsenal on Saturday night.
Cech's solid 'keeping and Liverpool's staunch defence ensured the match ended in a goalless stalemate
IMAGES from the Premier League matches played on Saturday